Anafranil is used in the management of obsessive-compulsive disorder (OCD). Obsessive-Compulsive Disorder (OCD) is a widespread, persistent and long-term disorder in which an individual has unmanageable, reoccurring obsessions and behaviors compulsions that he or she feels the urge to do again over and over.

The common indications shown by individuals suffering from OCD are obsessions, obligations, or both.

Obsessions are repetitive thoughts, urges, or psychological images that cause nervousness. Common indications include:-

  • Having things balanced or in a right order.
  • Too much dread of microbes or infection.
  • Destructive thoughts towards others or self.
  • Unnecessary prohibited or forbidden views involving intercourse, religion, and damage.

Compulsions are recurring behaviors that an individual with OCD experience the urge to do in reaction to a compelling thought. Common indications include:-

  • Too much cleaning and/or hand washing.
  • Ordering and arranging things in a particular, exact way.
  • Frequently checking on things.
  • Obsessive counting.

Not all behaviors or habits are obligations. Everybody check things from time to time. But an individual with OCD usually:

  • Spends too much time on these views or behaviors.
  • Doesn’t get delight when performing the behaviors or tasks, but may feel short respite from the unease the thoughts cause.
  • Faces considerable troubles in their routine due to these views or behaviors.
  • Is not able to control his or her views or behaviors, even when those views or behaviors are accepted as extreme.

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Anafranil contains Clomipramine as its main constituent that falls under the category of tricyclic depressants. Clomipramine possess a unique mode of action and function by inhibiting the reuptake of Serotonin (5-HT).

Do not take this drug, if you are allergic to Clomipramine or related compounds as it can result in severe hypersensitivity reactions. If you have a recent history of severe heart disorders like Heart Attack, then avoid the use of this drug. In case you have ingested Linezolid or a monoamine oxidase inhibitor (MAOI) within the last 2 weeks, do not take this drug as the risk of high blood pressure, heart disorders or seizures enhances.


Anafranil may interact with SSRI antidepressants like Fluvoxamine. Do not take Anafranil with these drugs as it may worsen its adverse effects. It may also interact with Barbiturates and Alpha blockers as they reduce its therapeutic activity. It should be kept away from the reach of children.


Anafranil is available in the form of both tablet and capsule. It comes under different strengths of 10mg, 25mg, 50mg and 75mg. The selection of the dose depends on the intensity and duration of the OCD. Take Anafranil orally with a glass of water. It will take at least 2-3 weeks for this medication to show its action. Do not discontinue its use even if you feel better. Take this drug regularly to get the desired results.

In case you miss a dose of Anafranil, then take it as soon as you remember. Do not take two doses of this drug at one time. Avoid administration of this drug in more than recommended amounts as it can lead to unpleasant effects.

Side effects: - Dry mouth, diarrhea, irritability and nightmares, upset stomach, nausea, etc. These unpleasant effects do not last for long and may disappear after the therapy is over.


Safety measures:-

  • Avoid consumption of Anafranil with alcoholic beverages as it can potentiate its adverse effects like lightheadedness and drowsiness.
  • The use of Anafranil is not recommended in case of children.
  • Generic Anafranil is not safe to use if you are pregnant or lactating.