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BRIMONIDINE (bri-MOE-ni-deen)+TIMOLOL (TIM-oh-lole)

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Quantity Strength Unit Price Price Cart
1 Bottle Combigan Solution 0.2-0.5 5ml Bottle $31.99 $31.99
3 Bottle Combigan Solution 0.2-0.5 5ml Bottle $31.33 $93.99


Generic Brimonidine and Timolol is a moderately selective alpha-2 adrenergic receptor agonist with a non-selective beta-adrenergic receptor inhibitor, which helps to treat this disorder by decreasing the pressure inside the eye. This medication is only used for open angle glaucoma.

Mechanism of action of Combigan

Brimonidine works by showing its action by stimulating alpha-2 adrenergic receptor and reducing the production of aqueous fluid, thereby decreasing the pressure in the humor chamber in the eye. Timolol is a beta-blocker receptor, that decrease the aqueous production in the eye and reduces the pressure in the eye.

Contraindication of Combigan

This drug is not to be used under certain medical conditions:

  • If the patient is having Allergic reactions to the generic of this medicine and other inactive components of this drug.
  • Patients who are suffering from disease conditions including Heart disease; auricular-ventricular dysfunction, bradycardia.
  • This medicine is not given to the neonates or under the age of 2 years.
  • Patients who are suffering from asthma should not take this drug.
  • Avoid taking this drug if you are suffering from Hepatic disorder.

Drug interactions of Combigan

This drug shows interaction when used in combination with certain enlisted drugs:

Monoamine Oxidase inhibitors, CYP3A4 inhibitors, CNS Depressants drug, Tricyclic antidepressants drug, Catecholamine-depleting Drugs, Calcium channel blockers drug, PDE5 inhibitors drug.

Dosage instruction and method of administration of Combigan

The recommended dose of Combigan is one drop twice a day. The route of administration is ocular. To instill the eye drop recline your head back and drag down eyelid to form a small pocket and instill the drops then don't open your eyes for 2-3 minutes.

Missed dose of Combigan

If you missed the dose take it as soon as you remember. But however, if it is already a time for your next dose then skip this dose and resume your regular dosing schedule.

Overdose of Combigan

Avoid taking an overdose of this drug because the overdose of this medicine is harmful to your health.

Storage conditions of Combigan

This drug is recommended to be stored at 15 to 25 ° C. This medicine should be protected from light and moisture. Do not touch the tip of the bottle to prevent contamination.

Side effects of Combigan

You may face certain side effects after administration of this drug:

Abnormal tearing, irritation of the eye, small bumps on inside layer of the eyelid, hypotension, impulsive loss of vision, asymmetrical heart rate, giddiness, Flushing, tiredness, confusion and inhalation difficulty.

Precautions of Combigan

You must follow some precautions before taking this medicine;

  • This drug to be used with caution in pregnant women and nursing mothers.
  • Avoid alcohol consumption while on treatment with this drug.
  • This drug may produce some dizziness so do not indulge in driving and other important work that needs your attention.
  • Always check the expiry on the vial before using.
  • This drug is only to be used in the eye.
  • Stop the usage of this drug if irritation occurs in the eye. 

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