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Sibelium is an orally administered drug which is used for the treatment of a migraine headache with and without aura. It is also used for the treatment of vertigo of central and peripheral origin, occlusive peripheral vascular disease and as an adjuvant in the therapy of epilepsy. Many times Sibelium has a notable effect to decrease the headache frequency and severity in both adults and children.

How Sibelium works?

The active constituent of Sibelium is Flunarizine. It is a calcium channel blocker that works by inhibiting the influx of extracellular calcium through myocardial and vascular membrane pores and decreasing the intracellular calcium that prohibits the contractile processes of smooth muscle cells, thereby causing dilation of the coronary and systemic arteries, and increased oxygen delivery to the myocardial tissue.

What are the contraindications of Sibelium?

  • This drug is contraindicated in the patients who are hypersensitive to the ingredient of Sibelium.
  • If you are suffering from stroke disease then do not use this drug.
  • You should not use this drug if you are suffering from Parkinson's disease
  • It should not be used in case you are suffering from uncontrolled blood pressure.
  • Do not use this drug if you have a cardiac disorder such as heart failure and arrhythmia.

What are the drug interactions of Sibelium?

You should not use following drugs while administering this medication:

  • Sedatives: Clonazepam, Clorazepate, Chlordiazepoxide, and Chloral hydrate
  • Anti-anxiety medicines: Diazepam, Alprazolam, and Lorazepam
  • Muscle relaxants: Carisoprodol, Dantrolene
  • Tranquilisers: Chlordiazepoxide, Diazepam
  • Anti-seizure medicines: Carbamazepine, Ethosuximide, Gabapentin, Lacosamide, Phenobarbital

How to store Sibelium:

Store Sibelium at room temperature 20 to 30oC; keep away from heat and moisture. Keep out of reach from children.

How to use Sibelium:

For migraine headaches, the recommended dose is 5 to 10 mg once daily.  Sibelium should be administered orally with a full glass of water. This drug should be started with a low dose as recommended by a doctor. Swallow whole tablet, do not chew or break.

Missed dose of Sibelium:

Administer as soon as possible if you missed the dose. You should skip if it is the time for next dose. Do not administer the double dose.

Over dose of Sibelium:

You should not use more than prescribed dose as it can cause adverse effects. In the case of over dose consult the doctor or you can go to the nearby hospital for medical help.  

Possible side effects of Sibelium:

Nausea, vomiting, weight gain, appetite increased, epigastric pain, heartburn, anxiety, depression, dizziness, menstrual irregularities, drowsiness, fatigue, insomnia, sedation, vertigo, muscle ache, and weakness

What are the precautions of Sibelium?

  • Alcohol consumption is prohibited while administering this drug as it can enhance the risk of side effects.
  • You should not drive after administering this drug as it causes side effects like dizziness, drowsiness, fatigue.
  • In the case of pregnancy and lactation this drug is prohibited as it can be harmful to the baby.

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